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Aging is really a continuum of your cell pools (somatic and stem cells) from healthy to the stages of cellular decline (quiescence, early senescence, late senescence, apoptosis, cancer). If apoptosis (programmed cell death) does not occur, we run the risk of developing the degenerative diseases of aging, including cancer. We believe in focusing on intervention earlier in the cell lifecycle, rather than treating the symptoms of aging once the cells are already damaged. This cycle is compounded by

The Cell Aging Continuum (from healthy through the stages of cellular decline) - Dr. Vincent Giampapa, MD, FACS

⏲ 2 min 2 sec ✓ 19-Apr-2016

PeerView Oncology

Antibody–Drug Conjugates for Solid Tumors: Progress, Possibilities, and Implications for Care

⏲ 1 hour 21 minutes 32 seconds 👁 514

Canadian Nuclear Safety Commission - CNSC

The Bystander Effect in Radiation Biology and its Relevance to Radiation Protection

⏲ 26 minutes 48 seconds 👁 1K

Time-lapse imaging capturing transfer of eGFP from a NV1066 virus-infected JMN mesothelioma cell to a non-infected cell after de novo TNT formation. From Ady et al., Tunneling nanotubes: an alternate route for propagation of the bystander effect following oncolytic viral infection, published in Molecular Therapy Oncolytics December 7, 2016. nnDirect link to article: http://www.nature.com/articles/mto201629

Intercellular transfer of oncolytic virus expressed GFP between cancer cells via a tunneling nanotube (TNT).

⏲ 17 sec ✓ 08-Dec-2016

Research Square

Radiation therapy might help, not harm, cancer cells

⏲ 1 minute 47 seconds 👁 248

Centers for Disease Control and Prevention (CDC)

Biological Effects of Radiation

⏲ 2 minutes 27 seconds 👁 246.1K

Additional time-lapse evidence of TNT formation between JMN (mesothelioma/cancer) cells infected or not infected with eGFP-expressing NV1066 virus (engineered form of oncolytic herpes simplex virus). Note the conformation of the TNT and its length >75 µm.nMovie S2 from Supplementary Information section of Ady et al., Tunneling nanotubes: an alternate route for propagation of the bystander effect following oncolytic viral infection, published in Molecular Therapy Oncolytics December 7, 2016. nnD

Long-range direct intercellular transfer of engineered therapeutic virus destroys recipient cancer cell.

⏲ 17 sec ✓ 08-Dec-2016

Scientific American

What Is the Bystander Effect?

⏲ 2 minutes 10 seconds 👁 49.4K

SciShow Psych

Is the Bystander Effect Real?

⏲ 5 minutes 9 seconds 👁 67.9K

MSTO-211H cells transfected with NV1066 form long-range connections via TNTs, which mediate intercellular transfer of virus-expressed eGFP. Cells were cultured in low serum, hyperglycemic medium for 48 hours.NV1066 HSV was added at MOI of 0.1.Time lapse images were captured every 10 seconds using a Zeiss LSM5 Live microscope.nPublished by Ady et al, Tunneling nanotubes: an alternate route for propagation of the bystander effect following oncolytic viral infection, Molecular Therapy-Oncolytic

Mesothelioma (cancer) cells form long-range connections (TNTs) that mediate intercellular transfer of GFP-expressing virus.

⏲ 20 sec ✓ 08-Dec-2016

European Society for Gene and Cell Therapy

ESGCT e-School: Adenoviral vectors – gene delivery tool, powerful weapon in cancer and beyond

⏲ 47 minutes 26 seconds 👁 810

Participant

The Bystander Effect | The Science of Empathy

⏲ 5 minutes 36 seconds 👁 460.5K

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